Summary: Dormancy enables relapsing malaria parasites, such as Plasmodium vivax and cynomolgi, to survive unfavorable conditions.It is enabled by hypnozoites, parasites remaining quiescent inside hepatocytes before reactivating and establishing blood-stage infection.We integrate omics approaches to explore gene-regulatory mechanisms underlying hypnozoite dormancy.
Genome-wide profiling of activating and repressing histone marks identifies a iphone 14 price texas few genes that get silenced by heterochromatin during hepatic infection of relapsing parasites.By combining single-cell transcriptomics, chromatin accessibility profiling, and fluorescent in situ RNA hybridization, we show that these genes are expressed in hypnozoites and that their silencing precedes parasite development.Intriguingly, these hypnozoite-specific genes mainly encode proteins with RNA-binding domains.
We hence hypothesize silver condenser tumble dryer that these likely repressive RNA-binding proteins keep hypnozoites in a developmentally competent but dormant state and that heterochromatin-mediated silencing of the corresponding genes aids reactivation.Exploring the regulation and exact function of these proteins hence could provide clues for targeted reactivation and killing of these latent pathogens.